CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse.
In most mammals, including mice and humans, meiotic recombination is determined by the meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences and trimethylates histone 3 at lysine-4 and lysine-36 at the adjacent nucleosomes.These actions ensure successful DNA Home Medical Equipment double strand break formation and r